Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Effect of salidroside on ventricular remodeling after acute myocardial infarction

Chun Zhou, Lu Jiao, Lin Teng, Jiawang Ding

The First College of Clinical Medical Science China Three Gorgers University, Yichang Central Peopleâ€™s Hospital Yichang 443000, Hubei Province, China;

For correspondence:- Jiawang Ding Email: zhouchun19860903@163.com

Accepted: 22 November 2022 Published: 29 December 2022

Citation: Zhou C, Jiao L, Teng L, Ding J. Effect of salidroside on ventricular remodeling after acute myocardial infarction. Trop J Pharm Res 2022; 21(12):2633-2638 doi: 10.4314/tjpr.v21i12.18

© 2022 The authors.
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Abstract

Purpose: To investigate the remodeling influence of salidroside (SAL) on the ventricles following acute myocardial infarction (AMI) in rats, and the processes involved.

Methods: A total of 65 Sprague Dawley (SD) rats were assigned to 5 groups: sham (n = 13), model, and low-, medium- and high-dose SAL groups given SAL at doses of 12, 34, and 36 mg/day, respectively, with 13 rats in each group. Changes in pathological structure, collagen area, ratio of collagen I/collagen III, left ventricular mass index (LVW/BW), ratio of cardiac weight to body weight (HW/BW), creatine kinase MB isoenzyme (CK-MB), lactate dehydrogenase-1 (LDH-1), endothelin (ET), laminin (LN), and hyaluronic acid (HA) were evaluated. expression levels of dishevelled-1 (DVL-1) and β-catenin in myocardial tissues of the rats were also determined.

Results: The LVW/BW values were significantly higher in the low SAL and medium SAL groups than those in AMI rats, while the ratio of collagen I/III and expression levels of DVL-1 and β-catenin proteins were significantly lower than those in the model group (p < 0.05). The myocardial structure of rats in the sham group was normal, with no obvious lesions. The levels of CK-MB, LDH-1, ET, LN, and HA in medium and high-dose SAL groups were significantly lower than those in the model group (p < 0.05).

Conclusion: Salidroside mitigates remodeling of ventricles following AMI in rats by modulating the Wnt/β-catenin signal route.

Keywords: Â Salidroside, Wnt, Î²-catenin, Acute myocardial infarction